Danger and reward typically journey hand-in-hand, making the inventory market each profitable and harmful. Among the many finest exemplars of this axiom are the penny shares, these equities priced at $5 or much less. With that low value comes the potential for excessive good points, as even an incrementally small value enhance will translate to a excessive share achieve.JPMorgan’s Head of Small and Midcap Fairness Technique, Eduardo Lecubarri, sees each the alternatives and risks within the present market surroundings – and the good potential of small-cap shares which have room to run.“1Q could also be rocky following the sturdy good points since Nov and the truth that valuations are sitting on all-time highs. Nonetheless, the 12 months lengthy outlook is encouraging on account of way more highly effective elementary tailwinds. Such a constructive backdrop is more likely to preserve traders chasing these few shares that also supply massive restoration upside, as they appear to have began to do YTD. It is for that reason that we might encourage traders to construct their portfolios now and see issues by way of within the occasion of any consolidation part that will are available in Q1,” Lecubarri wrote.Taking the danger into consideration, we used TipRanks’ database to seek out compelling penny shares with discount value tags. The platform steered us in the direction of two tickers sporting “Robust Purchase” consensus rankings from the analyst neighborhood. To not point out substantial upside potential is on the desk. We’re speaking returns of at the very least 300% over the following 12 months, in line with the analysts.AcelRx Prescription drugs (ACRX)Opioids have made headlines in recent times, and for all of the fallacious causes. These potent ache aid medication are additionally dangerously addictive – an element that has led to the opioid epidemic within the US. AcelRx is a pharmaceutical firm devoted to the creation of safer therapies for acute ache, creating artificial opioid medication for sublingual (beneath the tongue) dosing.The corporate’s principal product, Sufentanil, was permitted by the FDA beneath the identify Dsuvia in 2018, and by the EU as Dzuveo that very same 12 months. A second sublingual Sufentanil system, beneath the identify Zalviso, has additionally been permitted to be used by the EU, and is in Part 3 trial within the US.In its most up-to-date incomes report, the corporate confirmed $1.4 million on the prime line, pushed by $1.3 million in product gross sales. The gross sales determine was up 433% sequentially, and the entire income determine was up 133% year-over-year.Towards this backdrop, a number of members of the Road consider ACRX’s $1.40 share value seems like a steal.Cantor analyst Brandon Folkes is upbeat on Dsuvia’s prospects as an alternative choice to present opioid therapies, and he believes that potential will enhance the corporate’s inventory.“With the launch of Dsuvia, we consider investor focus can now shift to launch metrics and peak gross sales potential for the product. As ACRX launches a real different to IV opioids, we count on traders to start to understand the worth of the product. We consider that Dsuvia presents an development in supply of ample ache remedy by eliminating the necessity for an invasive and time-consuming IV set-up within the emergency room, in addition to an outpatient, or post-surgery, setting. Regardless of hospital launches taking time, we count on the uptake of Dsuvia to drive income upside past the Road’s present estimates, which, in flip, may drive the inventory greater from present ranges,” Follked opined.In keeping with his bullish stance, Folkes charges ACRX a Purchase, and his $9 value goal implies room for a surprising 552% upside potential within the subsequent 12 months. (To look at Folkes’ observe file, click on right here)Turning now to the remainder of the Road, 3 Buys and no Holds or Sells have been printed within the final three months. Subsequently, ACRX has a Robust Purchase consensus score. Primarily based on the $7 common value goal, shares may soar 407% within the subsequent 12 months. (See ACRX inventory evaluation on TipRanks)NuCana (NCNA)NuCana is a biopharma firm targeted on new most cancers therapies. The corporate’s objective is to offer efficient therapies for biliary, breast, colorectal, ovarian, and pancreatic cancers – whereas avoiding the problems and unwanted effects of present chemotherapy therapies. NuCana makes use of a phosphoramidate chemistry expertise referred to as ProTide to create a category of medicine that can surmount the constraints of the present nucleotide analogs behind many chemotherapy medication. NuCana’s ProTides have already been utilized in Gilead’s antiviral drug Sovaldi.In Could of final 12 months, NuCana introduced the restart of its Part III trial on Acelarin, the drug candidate furthest alongside the corporate’s pipeline, as a remedy for biliary tract cancers. The examine encompasses over 800 sufferers in 6 nations and is presently ongoing. In November, the corporate printed knowledge described as ‘encouraging’ from the Part Ib examine of the identical drug.Whereas Acelarin is the flagship drug within the pipeline, NuCana has two different prospects beneath improvement. NUC-3373 is in Part I trial as a remedy for stable tumors and colorectal cancers, and NUC-7738 is a second pathway beneath investigation for purposes to superior stable tumors. Of those three, the colorectal examine is the farthest superior.Writing from Truist, 5-star analyst Robyn Karnauskas sees the pipeline as key to NuCana’s investor potential.“We consider traders have neglected the truth that NCNA is a platform Firm that we consider is validated, as outlined by the manufacturing of medical merchandise. We like that it has introduced 3 merchandise to the clinic, together with one novel drug and two improved cornerstone chemos. The info counsel to us that the platform works and might produce higher chemos […] Whereas traders are largely targeted on Acelarin, we consider traders also needs to give attention to NUC-3373, one other core to our platform-based thesis that has knowledge anticipated in 1H2021,” Karnauskas famous.To this finish, Karnauskas places a $22 value goal on NCNA, suggesting the inventory has room for 384% development forward of it, together with a Purchase score. (To look at Karnauskas’ observe file, click on right here)General, NCNA’s Robust Purchase consensus score is unanimous, and based mostly on 4 latest evaluations. Shares have a mean value goal of $17.33, suggesting a 270% one-year upside from the present buying and selling value of $4.69. (See NCNA inventory evaluation on TipRanks)To search out good concepts for penny shares buying and selling at enticing valuations, go to TipRanks’ Finest Shares to Purchase, a newly launched device that unites all of TipRanks’ fairness insights.Disclaimer: The opinions expressed on this article are solely these of the featured analysts. The content material is meant for use for informational functions solely. It is rather necessary to do your individual evaluation earlier than making any funding.