(Reuters) – The next is a roundup of among the newest scientific research on the novel coronavirus and efforts to search out remedies and vaccines for COVID-19, the sickness attributable to the virus.
mRNA vaccines may have extra examine for treating some most cancers sufferers
COVID-19 vaccines that make use of new messenger RNA (mRNA) know-how to fend off the sickness could require additional testing earlier than it turns into clear they’re protected for most cancers sufferers with strong tumors, most cancers remedy consultants say. That would come with the vaccines from Pfizer Inc with accomplice BioNTech SE and from Moderna Inc. The vaccines work by carrying genetic directions for making a protein from the virus that the immune system learns to acknowledge and defend in opposition to. The mRNA is encased in a microscopic “packet” known as a lipid nanoparticle (LNP), or liposome, that protects and delivers the delicate molecule into cells. Whereas this system is new for vaccines, it has lengthy been used to hold most cancers medicine into tumors, as a result of tumors simply take up liposomes. This raises the likelihood that tumor tissues would seize among the liposomes carrying the vaccine’s mRNA, stated Gerard Milano of Good College in France. The potential for a part of the vaccine to develop into caught in tumors and the ensuing impact on most cancers sufferers “is an open query to which there’s at present no reply,” Milano stated. In a paper printed on Wednesday within the British Journal of Most cancers, his group requires “a cautious analysis of the efficacy of those promising mRNA COVID-19 vaccines administered as lipid carriers for sufferers with strong tumors, together with a attainable re-appraisal of the dosing for optimum safety of this particular and frail inhabitants.” (go.nature.com/2JQq4hV)
Stable sewage beats wastewater for monitoring COVID-19
Public well being officers making an attempt to trace the unfold of the brand new coronavirus is likely to be higher off searching for its genetic materials in strong sewage reasonably than in wastewater, a brand new examine suggests. For a number of days in March and April, researchers collected and analyzed wastewater and the solids that settled out of the water at two California sewage remedy crops. They reported on Wednesday in Environmental Science & Know-how that concentrations of genetic materials from the virus had been as much as 1,000 occasions increased within the solids than within the wastewater, making detection extra delicate and correct for the strong samples. In addition they analyzed settled solids collected over a number of months from waste remedy crops in a big city space and located that concentrations of genetic materials on completely different days correlated with the variety of new COVID-19 circumstances reported on these days. Coauthor Krista Wigginton of the College of Michigan stated that in comparison with extracting the virus from uncooked sewage, extracting it from solids “requires fewer steps and primarily the identical gear,” doubtlessly making it “a extra simple and extra delicate method” to COVID-19 surveillance. (bit.ly/3oAL9Ma)
Males worldwide doing worse with COVID-19
A big worldwide examine of COVID-19 sufferers confirms that males are extra probably than girls to develop into significantly unwell and die of the illness. Researchers pooled information from authorities web sites and the medical literature on greater than 3.1 million individuals contaminated with the brand new coronavirus in 46 international locations. They discovered no distinction within the proportion of female and male sufferers who contracted COVID-19. Males, nevertheless, had been almost 3 times extra more likely to be admitted to an intensive care unit and 39% extra more likely to die from COVID-19. In a report printed on Wednesday in Nature Communications, the investigators stated earlier research have discovered “basic variations” in the way in which males’s our bodies and girls’s our bodies reply to infections. In individuals with COVID-19, they write, “these variations are more likely to result in more practical viral management in females.” The information has necessary implications for managing sufferers and for public well being, the researchers stated. (go.nature.com/3qKEXTU)
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Reporting by Nancy Lapid; Enhancing by Invoice Berkrot