THURSDAY, Dec. 10, 2020 (HealthDay Information) — Kidney problems are the strongest preexisting issue related to COVID-19-related hospitalization, in response to a examine printed on-line Nov. 12 in PLOS ONE.
Matthew T. Oetjens, Ph.D., from the Geisinger Well being System in Danville, Pennsylvania, and colleagues used digital well being document knowledge to evaluate pre-COVID-19 pandemic medical phenotypes (12,971 people) related to hospital admission for COVID-19.
The researchers discovered that 1,604 sufferers have been extreme acute respiratory syndrome coronavirus 2-positive and 354 required hospitalization. Twenty-one medical phenotypes in 5 illness classes met phenome-wide significance, together with six kidney phenotypes (e.g., end-stage renal illness or stage 5 persistent kidney illness: odds ratio [OR], 11.07), six cardiovascular phenotypes (e.g., congestive coronary heart failure: OR, 3.8), 5 respiratory phenotypes (e.g., persistent airway obstruction: OR, 2.54), and three metabolic phenotypes (e.g., kind 2 diabetes: OR, 1.80). When defining persistent kidney illness primarily based on estimated glomerular filtration fee, a equally excessive threat of hospitalization was related to preexisting stage 4 persistent kidney illness (OR, 2.90), stage 5 persistent kidney illness with dialysis (OR, 8.83), and kidney transplant (OR, 14.98).
“Our group used a novel method made attainable by our intensive digital well being information, distinctive demographic knowledge, and built-in well being system,” a coauthor stated in an announcement. “We have been in a position to carry out this examine regardless of having a a lot decrease variety of COVID-19 instances in comparison with massive hospitals in metropolitan areas.”